S0501 Fludarabine, Melphalan, and Donor Stem Cell Transplant Followed By Tacrolimus and Methotrexate in Treating Patients for Relapsed Lymphoma
Stopped early · Phase 2
Conditions studied: Lymphoma
In brief
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and melphalan, before a donor bone marrow or peripheral blood stem cell transplant helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving tacrolimus and methotrexate after transplant may stop this from happening. PURPOSE: This phase II trial is studying how well giving fludarabine together with melphalan followed by tacrolimus and methotrexate works in treating patients who are undergoing a donor stem cell transplant for relapsed lymphoma.
Key facts
- Study ID
- NCT00121186
- Run by
- SWOG Cancer Research Network
- People needed
- 1
- Starts
- 2005-07-01
- Expected to finish
- 2011-12-01
- Last updated by the study team
- 2012-04-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cardinal Bernardin Cancer Center at Loyola University Medical Center — Maywood, Illinois, United States
- St. Francis Hospital and Health Centers - Beech Grove Campus — Beech Grove, Indiana, United States
- Reid Hospital & Health Care Services, Incorporated — Richmond, Indiana, United States
- Cancer Center of Kansas, PA - Chanute — Chanute, Kansas, United States
- Cancer Center of Kansas, PA - Dodge City — Dodge City, Kansas, United States
- Cancer Center of Kansas, PA - El Dorado — El Dorado, Kansas, United States
- Cancer Center of Kansas, PA - Kingman — Kingman, Kansas, United States
- Southwest Medical Center — Liberal, Kansas, United States
- Cancer Center of Kansas, PA - Newton — Newton, Kansas, United States
- Cancer Center of Kansas, PA - Parsons — Parsons, Kansas, United States
- Cancer Center of Kansas, PA - Pratt — Pratt, Kansas, United States
- Cancer Center of Kansas, PA - Salina — Salina, Kansas, United States
- Cancer Center of Kansas, PA - Wellington — Wellington, Kansas, United States
- Associates in Womens Health, PA - North Review — Wichita, Kansas, United States
- Cancer Center of Kansas, PA - Medical Arts Tower — Wichita, Kansas, United States
- Cancer Center of Kansas, PA - Wichita — Wichita, Kansas, United States
- CCOP - Wichita — Wichita, Kansas, United States
- Via Christi Cancer Center at Via Christi Regional Medical Center — Wichita, Kansas, United States
- Cancer Center of Kansas, PA - Winfield — Winfield, Kansas, United States
- Highland Hospital of Rochester — Rochester, New York, United States
- Interlakes Oncology/Hematology PC — Rochester, New York, United States
- James P. Wilmot Cancer Center at University of Rochester Medical Center — Rochester, New York, United States
- Grandview Hospital — Dayton, Ohio, United States
- Good Samaritan Hospital — Dayton, Ohio, United States
- David L. Rike Cancer Center at Miami Valley Hospital — Dayton, Ohio, United States
Full record on ClinicalTrials.gov
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