The Effect of Fasudil on Vascular Function in Humans

Completed · Phase 2

Conditions studied: Atherosclerosis, Hypercholesterolemia

In brief

The purpose of the study is to evaluate how the rho kinase inhibitor, fasudil, affects vascular function in patients with atherosclerosis and hyperlipidemia.

Key facts

Study ID

NCT00120718

Run by

Brigham and Women's Hospital

People needed

60

Starts

2002-06-01

Expected to finish

2007-01-01

Last updated by the study team

2008-09-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Coronary artery disease
• Hyperlipidemia -OR-
• Healthy adults

You may not qualify if…

• Unstable angina, myocardial infarction or revascularization within 3 months
• Symptomatic heart failure
• Creatinine > 3.0 mg/dl
• Liver enzymes > 3X upper limit of normal
• Chronic hypoxia
• Significant anemia
• Chronic inflammatory disease
• Pregnancy
• Willing to withdraw statins for duration of study

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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