Hemofiltration for Respiratory Failure After Bone Marrow Transplantation

Completed · Phase 2/Phase 3

Conditions studied: Bone Marrow Transplantation, Respiratory Insufficiency

In brief

For children undergoing bone marrow transplantation, respiratory failure is a devastating complication, with mortality expectations well above 60%. The researchers have devised a novel strategy that may greatly improve survival. Hemofiltration, a continuous form of dialysis, was designed as a therapy for critically ill patients with kidney failure. A semi-permeable membrane removes plasma water and solutes (up to about 35,000 Daltons molecular weight). The researchers have treated immuno-compromised children with respiratory failure with hemofiltration. Many inflammatory molecules are of a size well below the limit of the filter. Hemofiltration might remove a critical amount of this inflammatory material, attenuating the unregulated inflammatory response that is central to the development of respiratory failure and progression to multiple organ failure and death. The researchers are conducting a multi-center trial of early continuous hemofiltration for respiratory failure in children following bone marrow transplantation. The researchers will analyze blood and ultrafiltrate using sensitive proteomic methods to detect several inflammatory biochemicals known to be active in this disease, looking for evidence that early active hemofiltration alters the inflammatory response. The researchers will test whether 'early' hemofiltration produces greater survival from respiratory failure in this vulnerable population.

Key facts

Study ID

NCT00120575

Run by

Stanford University

People needed

6

Starts

2005-01-01

Expected to finish

2009-02-03

Last updated by the study team

2026-06-04

Who can join

Age: 0 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• hematopoietic stem cell recipient
• respiratory failure fulfilling ARDS criteria
• mechanical ventilation (invasive / non-invasive)

You may not qualify if…

• extracorporeal membrane oxygenation (ECMO)
• predominance of congestive heart failure
• code status: a patient must be willing to accept invasive mechanical ventilation if clinically indicated

Where it is running

• Children's Hospital and Research Center — Oakland, California, United States
• Children's Healthcare of Atlanta @ Egleston — Atlanta, Georgia, United States
• Duke University — Durham, North Carolina, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Children's Hospital of British Columbia — Vancouver, British Columbia, Canada
• University of Ulm — Ulm, Germany
• Great Ormond Street Hospital — London, United Kingdom

Full record on ClinicalTrials.gov

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