Cognitive Therapy for Recurrent Depression

Completed · Phase 3 · Has a placebo group

Conditions studied: Depression

In brief

This study determined the effectiveness of continuation phase cognitive therapy versus antidepressant medication in preventing relapse of depression in people with recurrent depression.

Key facts

Study ID

NCT00118404

Run by

University of Texas Southwestern Medical Center

People needed

523

Starts

2000-03-01

Expected to finish

2008-07-01

Last updated by the study team

2014-06-05

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Recurrent unipolar major depressive disorder
• Have experienced at least two episodes of major depression
• Have experienced at least one period of recovery during a depressive episode or have a history of dysthymia (a mood disorder characterized by depression) prior to the onset of current or past depressive episodes
• Willing and able to comply with all study requirements
• Able to speak and read English

You may not qualify if…

• Active alcohol or other substance dependence within 6 months prior to study entry
• Currently at risk for suicide
• Mood disorders due to a medical condition or substance abuse
• Bipolar, schizoaffective, obsessive compulsive, or eating disorders
• Schizophrenia
• Unable to stop mood-altering medications
• Current use of medication or diagnosis of a medical disorder that may cause depression (e.g., diabetes, head injury, stroke, cancer, multiple sclerosis)
• Previous failure to experience a reduction in depressive symptoms after 8 weeks of cognitive therapy with a certified therapist
• Previous failure to experience a reduction in depressive symptoms after 6 weeks of 40 mg of Prozac
• Pregnancy or plan to become pregnant in the next 11-12 months
• Unable to attend clinic twice weekly during business hours
• Unable to complete questionnaires

Where it is running

• University of Pittsburgh Medical Center Western Psychiatric Institute and Clinic — Pittsburgh, Pennsylvania, United States
• University of Texas Southwestern Medical Center at Dallas — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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