Tanespimycin in Treating Patients With Inoperable Locoregionally Advanced or Metastatic Thyroid Cancer
Completed · Phase 2
Conditions studied: Recurrent Thyroid Cancer, Stage IV Follicular Thyroid Cancer, Stage IV Papillary Thyroid Cancer, Thyroid Gland Medullary Carcinoma
In brief
This phase II trial is studying how well tanespimycin works in treating patients with inoperable locoregionally advanced or metastatic thyroid cancer. Drugs used in chemotherapy, such as tanespimycin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Key facts
- Study ID
- NCT00118248
- Run by
- National Cancer Institute (NCI)
- People needed
- 41
- Starts
- 2004-12-01
- Expected to finish
- 2012-04-01
- Last updated by the study team
- 2017-02-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of thyroid carcinoma of 1 of the following types:
- Medullary
- Differentiated
- Iodine I 131-resistant disease, defined as failure to incorporate and/or progression of measurable disease after treatment with iodine I 131
- Inoperable locoregionally advanced or metastatic disease
- Measurable disease, defined as ≥ 1 lesion ≥ 2.0 cm by conventional techniques OR ≥ 1.0 cm by spiral CT scan
- No active CNS metastases
- Performance status - ECOG 0-2
- Absolute neutrophil count ≥ 1,500/mm\^3
- Platelet count ≥ 100,000/mm\^3
- Hemoglobin ≥ 9.0 g/dL
- Bilirubin ≤ normal
- Alkaline phosphatase ≤ 2.5 times upper limit of normal (ULN)
- AST ≤ 1.5 times ULN
- Creatinine ≤ 1.5 times ULN
- QTc < 450 msec for male patients (470 msec for female patients)
- LVEF > 40% by MUGA
- DLCO ≥ 80%
- No cardiac symptoms ≥ grade 2
- No active ischemic heart disease within the past year
- No congenital long QT syndrome
- No left bundle branch block
- No history of serious ventricular arrhythmia (i.e., ventricular tachycardia or ventricular fibrillation ≥ 3 beats in a row)
- No myocardial infarction within the past year
- No New York Heart Association class III or IV congestive heart failure
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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