Rituximab and Combination Chemotherapy in Treating Patients With Diffuse Large B-Cell Non-Hodgkin's Lymphoma
Completed · Phase 3
Conditions studied: Large B Cell Lymphoma
In brief
This randomized phase III trial studies rituximab when given together with two different combination chemotherapy regimens to compare how well they work in treating patients with diffuse large B-cell non-Hodgkin's lymphoma. Monoclonal antibodies, such as rituximab, may block cancer growth in different ways by targeting certain cells. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving rituximab together with combination chemotherapy may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective when given with rituximab in treating diffuse large B-cell non-Hodgkin's lymphoma. PURPOSE: This randomized phase III trial is studying rituximab when given together with two different combination chemotherapy regimens to compare how well they work in treating patients with diffuse large B-cell lymphoma.
Key facts
- Study ID
- NCT00118209
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 524
- Starts
- 2005-05-01
- Expected to finish
- 2021-11-15
- Last updated by the study team
- 2021-11-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- Camino Medical Group - Treatment Center — Mountain View, California, United States
- Palo Alto Medical Foundation — Palo Alto, California, United States
- Naval Medical Center - San Diego — San Diego, California, United States
- Saint Helena Hospital — St. Helena, California, United States
- Eastern Connecticut Hematology and Oncology Associates — Norwich, Connecticut, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
- University of Illinois Cancer Center — Chicago, Illinois, United States
- Creticos Cancer Center at Advocate Illinois Masonic Medical Center — Chicago, Illinois, United States
- Cardinal Bernardin Cancer Center at Loyola University Medical Center — Maywood, Illinois, United States
- Alvin and Lois Lapidus Cancer Institute at Sinai Hospital — Baltimore, Maryland, United States
- National Naval Medical Center — Bethesda, Maryland, United States
- NIH - Warren Grant Magnuson Clinical Center — Bethesda, Maryland, United States
- Providence Cancer Institute at Providence Hospital - Southfield Campus — Southfield, Michigan, United States
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri, United States
- Christian Hospital Northeast-Northwest — St Louis, Missouri, United States
- New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care — Concord, New Hampshire, United States
- New Hampshire Oncology - Hematology, PA - Hooksett — Hooksett, New Hampshire, United States
- Charles R. Wood Cancer Center at Glens Falls Hospital — Glens Falls, New York, United States
- New York Weill Cornell Cancer Center at Cornell University — New York, New York, United States
- James P. Wilmot Cancer Center at University of Rochester Medical Center — Rochester, New York, United States
- Presbyterian Cancer Center at Presbyterian Hospital — Charlotte, North Carolina, United States
- Kinston Medical Specialists — Kinston, North Carolina, United States
- Iredell Memorial Hospital — Statesville, North Carolina, United States
Full record on ClinicalTrials.gov
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