Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania

Completed · Phase 4

Conditions studied: Impulse Control Disorders

In brief

The purpose of this study is to assess the extent of symptom remission in patients with trichotillomania following treatment with sertraline and/or behavior therapy.

Key facts

Study ID

NCT00118014

Run by

Massachusetts General Hospital

People needed

75

Starts

2000-01-01

Expected to finish

2004-08-01

Last updated by the study team

2008-05-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients will have a DSM-IV diagnosis of TTM.
• TTM symptoms for at least 4 months.
• Scalp as primary site of hair pulling.
• HPS score greater than or equal to 15 OR TTM Impact Scale score greater than 30.
• Written informed consent.
• Men or women aged 18-65 years old.
• Females of childbearing potential must have a negative serum beta-HCG pregnancy test.

You may not qualify if…

• Pregnant women or women of childbearing potential who are not using a medically accepted means of contraception.
• Patients who, in the investigator's judgement, pose a serious suicidal or homicidal risk.
• Serious or unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic, or hematologic disease. Patients on anticoagulant therapy.
• History of seizure disorder.
• Comorbid bipolar disorder, psychosis, organic mental disorder, or developmental disorder.
• If there is a history of substance abuse, patients must be in remission at least 6 months.
• Past trials of sertraline.
• Currently being treated with behavioral therapy, specifically habit reversal training, for TTM.
• Other medications for medical disorders that may interact with sertraline.

Where it is running

• Massachusetts General Hospital - OCD Clinic — Charlestown, Massachusetts, United States

Full record on ClinicalTrials.gov

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