Pemetrexed Disodium, Carboplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III Non-Small Cell Lung Cancer
Completed · Phase 2
Conditions studied: Lung Cancer
In brief
RATIONALE: Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also make tumor cells more sensitive to radiation therapy. Giving pemetrexed disodium, carboplatin, and radiation therapy together with cetuximab may kill more tumor cells. PURPOSE: This randomized phase II trial is studying how well giving pemetrexed disodium and carboplatin together with radiation therapy with or without cetuximab works in treating patients with stage III non-small cell lung cancer that cannot be removed by surgery.
Key facts
- Study ID
- NCT00117962
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 109
- Starts
- 2005-09-01
- Expected to finish
- 2012-09-01
- Last updated by the study team
- 2016-10-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Eden Medical Center — Castro Valley, California, United States
- Saint Rose Hospital — Hayward, California, United States
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- Highland General Hospital — Oakland, California, United States
- Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Valley Care Medical Center — Pleasanton, California, United States
- Doctors Medical Center - San Pablo Campus — San Pablo, California, United States
- Bendheim Cancer Center at Greenwich Hospital — Greenwich, Connecticut, United States
- Tunnell Cancer Center at Beebe Medical Center — Lewes, Delaware, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Sibley Memorial Hospital — Washington D.C., District of Columbia, United States
- Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
- Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- Louis A. Weiss Memorial Hospital — Chicago, Illinois, United States
- La Grange Memorial Hospital — La Grange, Illinois, United States
- Fort Wayne Medical Oncology and Hematology — Fort Wayne, Indiana, United States
- Hematology Oncology Associates of the Quad Cities — Bettendorf, Iowa, United States
- Iowa Blood and Cancer Care — Cedar Rapids, Iowa, United States
- St. Luke's Hospital — Cedar Rapids, Iowa, United States
- Mercy Regional Cancer Center at Mercy Medical Center — Cedar Rapids, Iowa, United States
- Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
- Greenebaum Cancer Center at University of Maryland Medical Center — Baltimore, Maryland, United States
- Arroyo Grande Community Hospital — Arroyo Grande, California, United States
Full record on ClinicalTrials.gov
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