Picoplatin as Second-Line Therapy for Patients With Small Cell Lung Cancer

Completed · Phase 2

Conditions studied: Small Cell Lung Cancer

In brief

This is a Phase II research study that is designed for patients who have small cell lung cancer (SCLC) that is no longer responding to treatment. Patients will receive picoplatin, a new platinum-based agent that is currently under investigation, in 21-day cycles.

Key facts

Study ID

NCT00116610

Run by

Poniard Pharmaceuticals

People needed

75

Starts

2005-06-01

Expected to finish

2008-03-01

Last updated by the study team

2009-01-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Prior radiotherapy that included > 30% of the bone marrow (i.e., the whole of the pelvis or half of the spine).
• Significant chronic or recent acute gastrointestinal disorder with diarrhea as a major symptom.
• Significant heart disease.
• Uncontrolled, untreated, unstable, or symptomatic brain tumors or central nervous system disease.
• Grade 2+ peripheral neuropathy (a condition caused by damage to the nerves in the peripheral nervous system).
• [Additional exclusion criteria apply.]

Where it is running

• Study Site — Los Angeles, California, United States
• Comprehensive Cancer Center — Palm Springs, California, United States
• Eastern Connecticut Hematology/Oncology — Norwich, Connecticut, United States
• Oncology Hematology Group of South Florida — Miami, Florida, United States
• H. Lee Moffitt Cancer Center — Tampa, Florida, United States
• Augusta Oncology Associates — Augusta, Georgia, United States
• Central Georgia Hematology Oncology Associates — Macon, Georgia, United States
• Georgia Cancer Specialists — Tucker, Georgia, United States
• Rush Medical College — Chicago, Illinois, United States
• Medical Center of Vincennes — Vincennes, Indiana, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• Markey Cancer Center, University of Kentucky — Lexington, Kentucky, United States
• The Ochsner Clinic — New Orleans, Louisiana, United States
• Louisiana State University Health Science Center — Shreveport, Louisiana, United States
• University of Missouri / Ellis Fischel Cancer Center — Columbia, Missouri, United States
• The Center for Cancer Care & Research — St Louis, Missouri, United States
• Hematology Oncology Centers of the Northern Rockies — Billings, Montana, United States
• V.A. Sierra Nevada Health Care — Reno, Nevada, United States
• Dartmouth-Hitchcock Medical Center Hematology/Oncology — Lebanon, New Hampshire, United States
• Mt. Sinai Medical Center — New York, New York, United States
• Southeastern Medical Oncology Center — Goldsboro, North Carolina, United States
• Providence Portland Medical Center — Portland, Oregon, United States
• Consultants in Medical Oncology & Hematology — Drexel Hill, Pennsylvania, United States
• South Carolina Oncology Associates, PA — Columbia, South Carolina, United States
• Genesis Cancer Center — Hot Springs, Arkansas, United States

Full record on ClinicalTrials.gov

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