Escitalopram for the Treatment of Obsessive Compulsive Disorder (OCD)
Completed · Phase 4
Conditions studied: Obsessive Compulsive Disorder
In brief
The purpose of this study is to assess the efficacy of Escitalopram in the treatment of obsessive compulsive disorder and to determine the optimal treatment dose.
Key facts
- Study ID
- NCT00116532
- Run by
- Massachusetts General Hospital
- People needed
- 30
- Starts
- 2002-10-01
- Expected to finish
- 2007-02-01
- Last updated by the study team
- 2007-04-24
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of OCD by DSM-IV
- Age 18-65
- Y-BOCS greater than 20
- Written informed consent
- Females of childbearing potential must have a negative serum or urinary beta-HCG test.
You may not qualify if…
- Pregnant women or women of childbearing potential who are not using a medically accepted means of contraception.
- Patients who, in the investigator's judgement, pose a serious suicidal or homicidal risk.
- Serious or unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic, or hematologic disease. Patients on anticoagulant therapy.
- History of seizure disorder
- Comorbid bipolar disorder, psychosis, organic mental disorder, or developmental disorder
- If there is a history of substance abuse, patients in remission at least 6 months.
- Currently being treated with behavioral therapy, specifically exposure and response prevention, for OCD.
- Other medications for medical disorders that may interfere with escitalopram
- Current major depression or prescribed an antidepressant for major depression within the past 12 months.
- Taken an SSRI medication within 2 weeks of beginning the study (4 weeks for fluoxetine).
- More than 1 adequate trial (at least 10 weeks at maximally tolerated dose) with another SSRI in the past.
Where it is running
- Massachusetts General Hospital - OCD Clinic — Charlestown, Massachusetts, United States
Full record on ClinicalTrials.gov
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