Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure
Completed · Phase 4 · Has a placebo group
Conditions studied: Hypertension, Hypotension, Edema, Congestive Heart Failure
In brief
The purpose of this study is to determine whether continuing or discontinuing furosemide (a diuretic) on the day of elective noncardiac surgery for those who take furosemide on a chronic basis, causes more intraoperative hypotension (low blood pressure) during surgery. Our hypothesis is that the usual practice of continuing furosemide on the day of surgery would contribute to more hypotension during surgery than discontinuing furosemide.
Key facts
- Study ID
- NCT00115726
- Run by
- University of Calgary
- People needed
- 198
- Starts
- 2000-09-01
- Expected to finish
- 2007-04-01
- Last updated by the study team
- 2008-02-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All adults referred to preoperative assessment clinics by surgeons for elective non-cardiac surgery who routinely take furosemide.
- Participants must also be able to give informed consent
You may not qualify if…
- Less than 18 years of age
- Have comorbid conditions with which brief periods of hypotension may be particularly harmful such as: 1) pregnancy; 2) baseline hypotension (systolic <100 mmHg at the preoperative assessment clinic); 3) autonomic dysfunction; 4) severe aortic stenosis.
- Patients who take furosemide only on an 'as needed basis' rather than 'regularly'.
- Those patients who take less than 10 mg of furosemide daily
- Those patients who are undergoing local anesthetic only surgical procedures
- Patients who are unwilling or unable to give informed consent.
Where it is running
- The Cleveland Clinic Foundation — Cleveland, Ohio, United States
- Foothills Hospital — Calgary, Alberta, Canada
- University of Western Ontario — London, Ontario, Canada
Full record on ClinicalTrials.gov
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