Comparison of Two Medication Adherence Strategies to Improve Asthma Treatment Adherence

Completed · Not applicable

Conditions studied: Asthma, Lung Diseases

In brief

This is a randomized, controlled study that will compare two medication adherence strategies in adults with moderate or severe persistent asthma as a method for improving or maintaining treatment adherence.

Key facts

Study ID

NCT00115323

Run by

University of Pennsylvania

People needed

397

Starts

2005-05-01

Expected to finish

2010-03-01

Last updated by the study team

2013-12-23

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Receiving treatment for asthma at one of the participating clinics
• Moderate or severe persistent asthma according to the NHLBI Guidelines
• Current use of prescribed inhaled corticosteroids
• Evidence of reversible airflow obstruction, as indicated by the following two criteria:
• FEV1pp AND less than 80% at the time of study entry or within the 3 years prior to study entry
• An increase of greater than 15% and 200ml in FEV1 with asthma treatment over the last 3 years (if there is no record of such improvement, participants will be evaluated via spirometry pre- and post-bronchodilator at the first study visit. An increase in FEV1 or FVC greater than 12% and 200 ml in FEV1 30 minutes following albuterol administration will represent evidence of reversible airflow obstruction. If a spirometer is not immediately available, participants may be evaluated using a peak flow meter, which reports a PEF. A PEFpp less than 80% and an improvement of at least 60 L per minute after the administration of albuterol will represent evidence of reversible airflow obstruction)
• Has a functional telephone or mobile phone

You may not qualify if…

• Significant lung or cardiac disease (other than hypertension)
• Psychiatric illness, such as mania or schizophrenia, that may make it impossible to understand or carry out the Problem Solving intervention

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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