SYNTAX Study: TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries
Status unconfirmed · Phase 3
Conditions studied: Coronary Artery Disease
In brief
The SYNTAX trial is designed to determine the best treatment for patients with complex coronary disease (blocked or narrowed arteries in both the right and left sides of the heart) by randomizing patients to receive either percutaneous coronary intervention (PCI) with polymer-based paclitaxel-eluting TAXUS stents or to coronary artery bypass surgery (CABG).
Key facts
- Study ID
- NCT00114972
- Run by
- Boston Scientific Corporation
- People needed
- 1800
- Starts
- 2005-03-01
- Expected to finish
- 2012-05-01
- Last updated by the study team
- 2010-06-23
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Three-vessel disease, left main disease or LM equivalent with or without 1, 2 or 3VD (left anterior descending [LAD], left circumflex [LCX], right coronary artery [RCA] territory)
- De novo lesions with at least 50% stenosis
- Myocardial ischemia (stable, unstable, silent)
You may not qualify if…
- Prior PCI or CABG
- Acute myocardial infarction (with creatinine kinase >2x upper limit of normal)
- Concomitant cardiac valve disease requiring surgical therapy (reconstruction or replacement)
- Participation or planned participation in another cardiovascular clinical study before 1 year follow-up is completed
- Inability to give informed consent due to mental condition, mental retardation, or language barrier
Where it is running
- Washington Hospital Center — Washington D.C., District of Columbia, United States
- Florida Cardiovascular Research — Atlantis, Florida, United States
- Munroe Medical Center — Ocala, Florida, United States
- Ocala Heart Institue — Ocala, Florida, United States
- Florida Hospital — Orlando, Florida, United States
- Evanston Hospital — Evanston, Illinois, United States
- Rockford Cardiology Research Foundation (St. Anthony's Medical Center) — Rockford, Illinois, United States
- University of Iowa Hospital and Clinics — Iowa City, Iowa, United States
- Maine Medical Center — Portland, Maine, United States
- Tufts New England Medical Center — Boston, Massachusetts, United States
- Cape Cod Hospital — Hyannis, Massachusetts, United States
- Cape Cod Research Institute — Hyannis, Massachusetts, United States
- Genesys Regional Medical Center — Grand Blanc, Michigan, United States
- Spectrum Health — Grand Rapids, Michigan, United States
- Cardiac & Vascular Research Center of Northern Michigan — Petoskey, Michigan, United States
- Abbott Northwestern Hospital — Minneapolis, Minnesota, United States
- Mayo Clinic — Rochester, Minnesota, United States
- St. Mary's Hospital — Rochester, Minnesota, United States
- SUNY - Stony Brook School of Medicine — Stony Brook, New York, United States
- SJH Cardiology Associates — Syracuse, New York, United States
- St. Joseph's Hospital Health Center — Syracuse, New York, United States
- LeBauer Cardiovascular Research Foundation — Greensboro, North Carolina, United States
- Cardiovascular and Thoracic Surgeons of Greensboro — Greensboro, North Carolina, United States
- Wake Medical Center — Raleigh, North Carolina, United States
- Mercy General Hospital — Sacramento, California, United States
Full record on ClinicalTrials.gov
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