Safety Study of Adult Mesenchymal Stem Cells (MSC) to Treat Acute Myocardial Infarction

Completed · Phase 1 · Has a placebo group

Conditions studied: Myocardial Infarction

In brief

The purpose of the study is to determine whether adult stem cells \[Provacel™(PUMP1)\] are safe and possibly effective in the treatment of acute myocardial infarction (heart attack).

Key facts

Study ID

NCT00114452

Run by

Mesoblast, Inc.

People needed

60

Starts

2005-03-22

Expected to finish

2008-04-24

Last updated by the study team

2020-03-10

Who can join

Age: 21 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female between 21 and 85 years old
• First heart attack within 1 to 10 days

You may not qualify if…

• Positive for HIV 1 and 2
• Previous heart attack
• Pacemaker or other device
• Pregnant or breastfeeding
• Allergic to cow or pig derived products
• Previous bone marrow transplant
• Involved in another clinical trial within the past 30 days
• Alcohol or recreational drug abuse within the past 6 months
• Hepatitis Positive
• Major surgical procedure or major trauma within the past 14 days
• Body weight greater than 300 pounds
• Autoimmune disease ( e.g. Lupus, Multiple Sclerosis)

Where it is running

• Arizona Heart Institute — Phoenix, Arizona, United States
• University of California - San Diego; Thornton — San Diego, California, United States
• Washington Hospital Center — Washington D.C., District of Columbia, United States
• Rush University Medical Center — Chicago, Illinois, United States
• The Care Group — Indianapolis, Indiana, United States
• Jewish Hospital — Louisville, Kentucky, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Washington Adventist — Takoma Park, Maryland, United States
• Minneapolis Heart Institute — Minneapolis, Minnesota, United States
• Columbia Presbyterian Hospital — New York, New York, United States
• University of Rochester - Strong Memorial — Rochester, New York, United States
• University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
• University of Pennsylvania Medical Center — Philadelphia, Pennsylvania, United States
• Austin Heart Institute — Austin, Texas, United States
• Texas Medical School — Houston, Texas, United States

Full record on ClinicalTrials.gov

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