Letrozole With or Without Zoledronate in Treating Healthy Postmenopausal Women With High Breast Density

Completed · Not applicable

Conditions studied: Breast Cancer, Osteoporosis

In brief

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. Estrogen can cause the growth of breast cancer cells. Hormone therapy using letrozole may prevent breast cancer by lowering the amount of estrogen the body makes. Zoledronate may prevent bone loss caused by letrozole. Giving letrozole together with zoledronate may prevent breast cancer and reduce bone loss. PURPOSE: This randomized clinical trial is studying letrozole and zoledronate to see how well they work compared to letrozole and placebo or placebo alone in treating healthy postmenopausal women with high breast density.

Key facts

Study ID

NCT00114270

Run by

University of Virginia

Starts

2004-05-01

Expected to finish

2007-06-01

Last updated by the study team

2013-03-26

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

Where it is running

• University of Virginia Cancer Center — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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