Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Stage I Rectal Cancer

Completed · Phase 2

Conditions studied: Colorectal Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Oxaliplatin may make tumor cells more sensitive to radiation therapy. Giving capecitabine and oxaliplatin together with radiation therapy before surgery may shrink the tumor so it can be removed. PURPOSE: This phase II trial is studying how well giving capecitabine and oxaliplatin together with radiation therapy works in treating patients who are undergoing surgery for stage I rectal cancer.

Key facts

Study ID

NCT00114231

Run by

Alliance for Clinical Trials in Oncology

People needed

90

Starts

2006-05-01

Expected to finish

2014-12-01

Last updated by the study team

2018-03-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Cancer Care Center at John Muir Health - Concord Campus — Concord, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center — Orange, California, United States
• John Muir/Mt. Diablo Comprehensive Cancer Center — Walnut Creek, California, United States
• St. Vincent's Medical Center — Bridgeport, Connecticut, United States
• Praxair Cancer Center at Danbury Hospital — Danbury, Connecticut, United States
• Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
• Tampa General Hospital — Tampa, Florida, United States
• Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
• Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler — Savannah, Georgia, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• St. Francis Hospital and Health Centers - Beech Grove Campus — Beech Grove, Indiana, United States
• Indiana University Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
• William N. Wishard Memorial Hospital — Indianapolis, Indiana, United States
• Reid Hospital & Health Care Services — Richmond, Indiana, United States
• Ochsner Cancer Institute at Ochsner Clinic Foundation — New Orleans, Louisiana, United States
• Mayo Clinic Cancer Center — Rochester, Minnesota, United States
• Altru Cancer Center at Altru Hospital — Grand Forks, North Dakota, United States
• Grandview Hospital — Dayton, Ohio, United States
• Good Samaritan Hospital — Dayton, Ohio, United States
• David L. Rike Cancer Center at Miami Valley Hospital — Dayton, Ohio, United States
• Samaritan North Cancer Care Center — Dayton, Ohio, United States
• Veterans Affairs Medical Center - Dayton — Dayton, Ohio, United States
• Mayo Clinic Scottsdale — Scottsdale, Arizona, United States

Full record on ClinicalTrials.gov

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