Temozolomide and Radiation Therapy in Treating Patients With Gliomas
Completed · Phase 2
Conditions studied: Brain and Central Nervous System Tumors
In brief
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving temozolomide together with radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving temozolomide together with radiation therapy works in treating patients with low-grade gliomas.
Key facts
- Study ID
- NCT00114140
- Run by
- Radiation Therapy Oncology Group
- People needed
- 136
- Starts
- 2005-01-01
- Expected to finish
- 2022-05-20
- Last updated by the study team
- 2024-07-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Oncology Services Foundation — Phoenix, Arizona, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- University of Florida Shands Cancer Center — Gainesville, Florida, United States
- Baptist Cancer Institute - Jacksonville — Jacksonville, Florida, United States
- Integrated Community Oncology Network at Southside Cancer Center — Jacksonville, Florida, United States
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Baptist Medical Center South — Jacksonville, Florida, United States
- Integrated Community Oncology Network — Jacksonville Beach, Florida, United States
- Integrated Community Oncology Network - Orange Park — Orange Park, Florida, United States
- Florida Cancer Center - Palatka — Palatka, Florida, United States
- Flagler Cancer Center — Saint Augustine, Florida, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- DeCesaris Cancer Institute at Anne Arundel Medical Center — Annapolis, Maryland, United States
- Greenebaum Cancer Center at University of Maryland Medical Center — Baltimore, Maryland, United States
- University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
- Josephine Ford Cancer Center at Henry Ford Hospital — Detroit, Michigan, United States
- West Michigan Cancer Center — Kalamazoo, Michigan, United States
- Sparrow Regional Cancer Center — Lansing, Michigan, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- CCOP - Kansas City — Kansas City, Missouri, United States
- Methodist Estabrook Cancer Center — Omaha, Nebraska, United States
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- Mission Hospitals - Memorial Campus — Asheville, North Carolina, United States
Full record on ClinicalTrials.gov
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