Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury

Completed · Not applicable

Conditions studied: Respiratory Distress Syndrome, Adult, Head Injuries, Closed, Shock, Shock, Traumatic

In brief

The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD) resuscitation; also, to focus specifically on neurologic outcome in patients with brain injury and on the effect of HSD resuscitation on inflammatory cell responsiveness.

Key facts

Study ID

NCT00113685

Run by

University of Washington

People needed

209

Starts

2003-04-01

Expected to finish

2007-03-01

Last updated by the study team

2021-05-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Recent blunt trauma
• Of adult size if age is unknown
• Pre-hospital systolic bloood pressure 90 mm Hg or less
• Altered mental status
• Transported directly to Harborview Medical Center from the injury event

You may not qualify if…

• Ongoing CPR
• Transferred from outside hospitals
• Pregnant or suspected pregnancy
• Presence of injuries from penetrating trauma
• Receiving more than 2000 cc of crystaloid prior to study fluid administration

Where it is running

• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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