Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery
Stopped early · Phase 3
Conditions studied: Head and Neck Cancer
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cisplatin and paclitaxel may make tumor cells more sensitive to radiation therapy. Giving more than one drug (combination chemotherapy) and giving them with radiation therapy may kill more tumor cells. It is not yet known whether giving radiation therapy together with combination chemotherapy is more effective than giving combination chemotherapy alone in treating head and neck cancer. PURPOSE: This randomized phase III trial is studying radiation therapy and combination chemotherapy to see how well they work compared to combination chemotherapy alone in treating patients with recurrent head and neck cancer that cannot be removed by surgery.
Key facts
- Study ID
- NCT00113399
- Run by
- Radiation Therapy Oncology Group
- People needed
- 15
- Starts
- 2005-04-01
- Last updated by the study team
- 2013-07-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mobile Infirmary Medical Center — Mobile, Alabama, United States
- St. Joseph's Mercy Cancer Center — Hot Springs, Arkansas, United States
- Auburn Radiation Oncology — Auburn, California, United States
- Radiation Oncology Centers - Cameron Park — Cameron Park, California, United States
- Mercy Cancer Center at Mercy San Juan Medical Center — Carmichael, California, United States
- Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center — Pomona, California, United States
- Radiation Oncology Center - Roseville — Roseville, California, United States
- Radiological Associates of Sacramento Medical Group, Incorporated — Sacramento, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- Mercy General Hospital — Sacramento, California, United States
- Solano Radiation Oncology Center — Vacaville, California, United States
- Lynn Regional Cancer Center at Boca Raton Community Hospital - Main Center — Boca Raton, Florida, United States
- Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital — Fort Lauderdale, Florida, United States
- University of Florida Shands Cancer Center — Gainesville, Florida, United States
- Ella Milbank Foshay Cancer Center at Jupiter Medical Center — Jupiter, Florida, United States
- University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
- CCOP - Mount Sinai Medical Center — Miami Beach, Florida, United States
- H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa, Florida, United States
- MBCCOP - Medical College of Georgia Cancer Center — Augusta, Georgia, United States
- Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler — Savannah, Georgia, United States
- Saint Anthony's Hospital at Saint Anthony's Health Center — Alton, Illinois, United States
- Rush-Copley Cancer Care Center — Aurora, Illinois, United States
- Joliet Oncology-Hematology Associates, Limited - West — Joliet, Illinois, United States
- Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields — Olympia Fields, Illinois, United States
- University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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