Cisplatin and Docetaxel With or Without Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Newly Diagnosed Stage III Non-Small Cell Lung Cancer

Stopped early · Phase 3

Conditions studied: Lung Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Cisplatin and docetaxel may make tumor cells more sensitive to radiation therapy. Giving more than one drug (combination chemotherapy) together with radiation therapy before surgery may shrink the tumor so it can be removed. Giving chemotherapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether giving cisplatin and docetaxel together with radiation therapy is more effective than giving cisplatin together with docetaxel in treating non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying cisplatin, docetaxel, and radiation therapy to see how well they work compared to cisplatin and docetaxel in treating patients who are undergoing surgery for newly diagnosed stage III non-small cell lung cancer.

Key facts

Study ID

NCT00113386

Run by

Radiation Therapy Oncology Group

People needed

19

Starts

2005-04-01

Last updated by the study team

2013-06-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Cancer Care Center at John Muir Health - Concord Campus — Concord, California, United States
• Moores UCSD Cancer Center — La Jolla, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• University of California Davis Cancer Center — Sacramento, California, United States
• Memorial Hospital — Colorado Springs, Colorado, United States
• Front Range Cancer Specialists — Fort Collins, Colorado, United States
• Poudre Valley Hospital — Fort Collins, Colorado, United States
• CCOP - Christiana Care Health Services — Newark, Delaware, United States
• Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
• Ella Milbank Foshay Cancer Center at Jupiter Medical Center — Jupiter, Florida, United States
• Watson Clinic, LLC — Lakeland, Florida, United States
• CCOP - Mount Sinai Medical Center — Miami Beach, Florida, United States
• Phoebe Cancer Center at Phoebe Putney Memorial Hospital — Albany, Georgia, United States
• CCOP - Atlanta Regional — Atlanta, Georgia, United States
• Northeast Georgia Medical Center — Gainesville, Georgia, United States
• Delnor Community Hospital - Geneva — Geneva, Illinois, United States
• Cardinal Bernardin Cancer Center at Loyola University Medical Center — Maywood, Illinois, United States
• Community Cancer Center — Normal, Illinois, United States
• Advocate Christ Medical Center — Oak Lawn, Illinois, United States
• Cancer Treatment Center at Pekin Hospital — Pekin, Illinois, United States
• Oncology Hematology Associates of Central Illinois, PC - Peoria — Peoria, Illinois, United States
• OSF St. Francis Medical Center — Peoria, Illinois, United States
• Cancer Institute at St. John's Hospital — Springfield, Illinois, United States
• Cancer Center at Providence Alaska Medical Center — Anchorage, Alaska, United States

Full record on ClinicalTrials.gov

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