Preventing Weight Gain and Controlling Blood Pressure During Smoking Cessation in Hypertensive Smokers

Completed · Not applicable

Conditions studied: Cardiovascular Diseases, Heart Diseases, Hypertension

In brief

The purpose of this study is to develop effective interventions that assist individuals with high blood pressure to quit smoking and prevent weight gain.

Key facts

Study ID

NCT00113074

Run by

Mark Vander Weg

People needed

139

Starts

2004-09-01

Expected to finish

2011-06-01

Last updated by the study team

2024-04-29

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Smoke at least 5 cigarettes/day (or have quit within the last 6 weeks to enter the study for the weight gain prevention and BP control interventions)
• Pre-hypertensive or Stage I hypertension (systolic BP from 120 to 159 and/or diastolic BP from 80 to 99 mm Hg). Antihypertensive medications are not criteria for exclusion provided that BP is not over 160/100 mm Hg)
• Access to a telephone

You may not qualify if…

• History of unstable cardiovascular disease, including myocardial infarction, stroke, and unstable angina within three months of study start
• Coronary artery bypass grafting or angioplasty/stent within three months of study start
• Cardiac dysrhythmia treated with anti-arrhythmia medication, except stable atrial fibrillation
• Untreated hyperthyroidism or pheochromocytoma
• History of congestive heart failure (NYHA Class III or IV)
• ECG evidence of 2nd or 3rd degree atrioventricular block
• Uncontrolled or Stage II Hypertension as defined as BP consistently above 160/100 mm Hg
• History of severe liver or kidney failure
• Current substance abuse (includes alcohol use in excess of 21 drinks a week)
• Presence of an unstable psychiatric condition
• Severe chronic obstructive pulmonary disease
• Symptomatic peripheral vascular disease
• Pulmonary hypertension with shortness of breath
• Congenital or valvular heart disease with shortness of breath
• Current use of a medication that may interfere with primary study endpoints or that may increase the risk of side effects from study medication that cannot be discontinued
• Pregnant or plans to become pregnant within the next year
• Planning to move out of the area or travel extensively during the intervention
• Any medical condition that would preclude any additional changes in diet
• Unable to further modify physical activity routine
• Cannot engage in moderate intensity exercise (e.g., walking)

Where it is running

• University of Iowa, Carver College of Medicine, Department of Internal Medicine, Division of General Internal Medicine — Iowa City, Iowa, United States
• Mayo Clinic College of Medicine — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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