Effect of Exercise on Elevated C-reactive Protein Concentrations in Formerly Inactive Adults
Completed · Not applicable
Conditions studied: Cardiovascular Diseases, Heart Diseases, Obesity
In brief
The purpose of this study is to determine the effect of exercise training on elevated C-reactive protein (CRP) concentrations, an indicator of inflammation, in initially inactive women and men.
Key facts
- Study ID
- NCT00113061
- Run by
- National Heart, Lung, and Blood Institute (NHLBI)
- People needed
- 162
- Starts
- 2004-07-01
- Expected to finish
- 2006-06-01
- Last updated by the study team
- 2016-07-29
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Physically inactive
- C-reactive protein level at least 2.0 mg/L but less than 10.0 mg/L upon study entry
- Body mass index between 18.5 kg/square meter and 40.0 kg/square meter as measured at study entry
- Does not smoke
- Total cholesterol at least 240 mg/dl with LDL-C at least 160 mg/dl OR LDL less than 190 mg/dl and Framingham less than 10%
- Triglyceride levels no higher than 300 mg/dl
- Fasting glucose level less than 126
- Systolic blood pressure less than 140 mm Hg and/or diastolic blood pressure less than 90 mm Hg as measured at study entry
- If taking an oral contraceptive, aspirin, ibuprofen, or other anti-inflammatory medications, must be on a stable dose for 6 months prior to study entry
- If taking a cholesterol medication, including statins, blood pressure medication (including ace inhibitors), or multi-vitamins, must be on a stable dose for 2 months prior to study entry
You may not qualify if…
- Using a beta blocker, hormone replacement therapy, or corticosteroids (except inhalers)
- Any rheumatologic, orthopedic, neurological, or autoimmune diseases, or seizure disorder
- Any significant cardiovascular disease or disorders including, but not limited to, stent or coronary artery bypass grafting
- Cardiac dysrhythmias including, but not limited to, left bundle branch block, atrial fibrillation, pacemaker, or automatic implantable cardioverter defibrillator
- Any surgery, broken bones, blood donation, or anaphylactic shock within 6 months of study entry
- Any sprain or strain, removal of wisdom teeth, or use of antibiotics within 3 months of study entry
- History of stroke or TIA
- History of cancer within at least 5 years of study entry
- Diabetes or glucose intolerance
- Planning on participating in any other research trials during the next year
- Currently pregnant
- Planning to becoming pregnant during the next year
Where it is running
- Pennington Biomedical Research Center, LSU System — Baton Rouge, Louisiana, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.