Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer
Completed · Phase 3 · Has a placebo group
Conditions studied: Neurotoxicity, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
In brief
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemoprotective drugs, such as alpha-lipoic acid, may protect normal cells from the side effects of chemotherapy. Alpha-lipoic acid may also prevent damage to nerves that carry information to and from the brain and spinal cord to the rest of the body. It is not known whether alpha-lipoic acid is more effective than placebo in preventing peripheral neuropathy. PURPOSE: This randomized phase III trial is studying alpha-lipoic acid to see how well it works compared to placebo in preventing peripheral neuropathy in patients receiving chemotherapy for cancer.
Key facts
- Study ID
- NCT00112996
- Run by
- M.D. Anderson Cancer Center
- People needed
- 244
- Starts
- 2007-01-01
- Expected to finish
- 2014-04-01
- Last updated by the study team
- 2014-04-08
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith, Arkansas, United States
- Horizon Oncology Center — Lafayette, Indiana, United States
- CCOP - Wichita — Wichita, Kansas, United States
- Cabrini Center for Cancer Care at Christus St. Frances Cabrini Hospital — Alexandria, Louisiana, United States
- CCOP - Kalamazoo — Kalamazoo, Michigan, United States
- CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
- Cancer Research for the Ozarks — Springfield, Missouri, United States
- CCOP - Columbia River Oncology Program — Portland, Oregon, United States
- CCOP - Main Line Health — Wynnewood, Pennsylvania, United States
- CCOP - Greenville — Greenville, South Carolina, United States
- University of Texas M.D. Anderson CCOP Research Base — Houston, Texas, United States
- CCOP - Scott and White Hospital — Temple, Texas, United States
- Marshfield Clinic - Marshfield Center — Marshfield, Wisconsin, United States
Full record on ClinicalTrials.gov
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