Temozolomide Alone or in Combination With Thalidomide and/or Isotretinoin and/or Celecoxib in Treating Patients Who Have Undergone Radiation Therapy for Glioblastoma Multiforme
Completed · Phase 2
Conditions studied: Brain and Central Nervous System Tumors, Glioblastoma Multiforme
In brief
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Thalidomide may stop the growth of glioblastoma multiforme by blocking blood flow to the tumor. Isotretinoin may help cells that are involved in the body's immune response to work better. Celecoxib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known which temozolomide-containing regimen is more effective in treating glioblastoma multiforme. PURPOSE: This randomized phase II trial is studying eight different temozolomide-containing regimens to compare how well they work in treating patients who have undergone radiation therapy for glioblastoma multiforme.
Key facts
- Study ID
- NCT00112502
- Run by
- M.D. Anderson Cancer Center
- People needed
- 178
- Starts
- 2005-09-01
- Expected to finish
- 2014-09-01
- Last updated by the study team
- 2021-10-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith, Arkansas, United States
- University of Texas MD Anderson Cancer Center at Orlando — Orlando, Florida, United States
- CCOP - Atlanta Regional — Atlanta, Georgia, United States
- CCOP - Central Illinois — Decatur, Illinois, United States
- CCOP - Wichita — Wichita, Kansas, United States
- CCOP - Grand Rapids — Grand Rapids, Michigan, United States
- CCOP - Kalamazoo — Kalamazoo, Michigan, United States
- CCOP - Kansas City — Kansas City, Missouri, United States
- Cancer Research for the Ozarks — Springfield, Missouri, United States
- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
- CCOP - Upstate Carolina — Spartanburg, South Carolina, United States
- University of Texas MD Anderson Cancer Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
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