Defining Central Circuits of Pain

Completed · Not applicable

Conditions studied: Dyspepsia

In brief

The purpose of the study is to use functional Magnetic Resonance Imaging (MRI) to help us understand what parts of the subject's brain are involved when he experiences visceral pain, or pain in the gut. To stimulate the brain, he will be infused with a liquid meal (Ensure) into his stomach until he is maximally full. Magnetic resonance imaging (MRI) is a technique for making images (pictures) of the brain; it uses magnetic fields and radio waves and is not harmful. This study uses a new investigational technique called functional MRI (fMRI), which is a very fast MRI technique that will allow the investigators to evaluate changes in how blood flows to parts of his brain.

Key facts

Study ID

NCT00112333

Run by

Massachusetts General Hospital

People needed

60

Starts

2003-10-01

Expected to finish

2011-02-01

Last updated by the study team

2011-07-20

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Right handed men and non-pregnant women ages 18 to 64

You may not qualify if…

• Diabetes
• History of aspiration or severe respiratory complications linked to gastrointestinal disease
• Use of any over the counter medications within 7 days of the study
• Current or previous history of gastric surgery
• Use of any medications which may alter gastrointestinal motility

Where it is running

• Martinos Center for Biomedical Imaging — Charlestown, Massachusetts, United States

Full record on ClinicalTrials.gov

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