Biological Effects of Dehydroepiandrosterone (DHEA) in the Elderly

Completed · Not applicable

Conditions studied: Healthy

In brief

The purpose of the study is to examine whether DHEA replacement therapy is associated with beneficial changes in body composition (i.e., increases in lean mass and bone mass, and decreases in fat mass).

Key facts

Study ID

NCT00111930

Run by

National Institute on Aging (NIA)

People needed

144

Starts

2000-08-01

Expected to finish

2005-03-01

Last updated by the study team

2009-12-11

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy women and men
• Age 60 or older
• Age-appropriate DHEAS levels, but 70% lower than normal DHEAS levels for a 25-year old

You may not qualify if…

• Contraindications to DHEA treatment (personal history of breast cancer or other estrogen-dependent neoplasms, acute liver disease, undiagnosed vaginal bleeding in women, history or evidence of prostate cancer or benign prostatic hyperplasia (BPH) in men)
• Angina
• Resting blood pressure over 180/95
• Chronic infections
• Hypothyroidism
• Depression
• Hormone therapy within the previous 6 months
• Insulin-dependent or poorly controlled diabetes
• Serum DHEAS level greater than 140 micrograms per deciliter (µg/dL)
• Prohibited Medications:
• Hormone therapy other than stable regimen of thyroid replacement
• Oral glucocorticoids
• Insulin

Where it is running

• University of Colorado at Denver and Health Sciences Center — Denver, Colorado, United States

Full record on ClinicalTrials.gov

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