Study of Home-Based Resistance and Strength Training in HIV-Infected Women

Completed · Not applicable

Conditions studied: HIV Infections

In brief

Lipodystrophy is characterized by increased cardiovascular disease. Limited strategies are available to increase cardiovascular fitness in this population, particularly among women. Progressive aerobic and resistance training will increase aerobic capacity and improve strength in HIV positive women with lipodystrophy.

Key facts

Study ID

NCT00111332

Run by

Massachusetts General Hospital

People needed

40

Starts

2002-11-01

Expected to finish

2005-07-01

Last updated by the study team

2010-04-14

Who can join

Age: 18 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with documented HIV infection, by Western blot or ELISA
• Ages 18-60
• Self-report AND physical evidence, as assessed by the investigators, of at least one of the following:
• increased abdominal girth;
• relative loss of fat in the face;
• relative loss of fat in the extremities; *dorsocervical fat pad;
• relative increased breast size;
• a score greater than or equal to 1.5 on the Lipodystrophy Scale and a waist to hip ratio of greater than or equal to 0.85.

You may not qualify if…

• Pregnant or actively seeking pregnancy
• Breastfeeding
• New opportunistic infection diagnosed within 4 weeks of the study
• Pharmacologic glucocorticoid therapy (> 7.5 mg Prednisone or its equivalent/day)
• Androgen, growth hormone or Megace within 3 months of study initiation
• New anti-retroviral therapy within 1 month of the study
• SGOT > 5x normal and/or clinically significant liver disease
• Creatinine > 2.0 mg/dL and/or clinically significant renal disease
• Hemoglobin (Hgb) < 8.0g/dL
• Active substance abuse

Where it is running

• Mass General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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