S0414 Cetuximab, Combo Chemo, and RT in Locally Advanced Esophageal Cancer
Stopped early · Phase 2
Conditions studied: Esophageal Cancer
In brief
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also stop the growth of esophageal cancer by blocking blood flow to the tumor and by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving cetuximab together with combination chemotherapy and radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving cetuximab together with combination chemotherapy and radiation therapy works in treating patients with locally advanced esophageal cancer that cannot be removed by surgery.
Key facts
- Study ID
- NCT00109850
- Run by
- SWOG Cancer Research Network
- People needed
- 22
- Starts
- 2005-05-01
- Expected to finish
- 2012-05-01
- Last updated by the study team
- 2015-11-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Alta Bates Comprehensive Cancer Center — Berkeley, California, United States
- Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
- Peninsula Medical Center — Burlingame, California, United States
- Eden Medical Center — Castro Valley, California, United States
- Marin Cancer Institute at Marin General Hospital — Greenbrae, California, United States
- Sutter Health - Western Division Cancer Research Group — Greenbrae, California, United States
- Saint Rose Hospital — Hayward, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Highland General Hospital — Oakland, California, United States
- Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Desert Regional Medical Center Comprehensive Cancer Center — Palm Springs, California, United States
- Valley Care Medical Center — Pleasanton, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- California Pacific Medical Center - California Campus — San Francisco, California, United States
- Doctors Medical Center - San Pablo Campus — San Pablo, California, United States
- CCOP - Santa Rosa Memorial Hospital — Sana Rosa, California, United States
- Sutter Solano Medical Center — Vallejo, California, United States
- Poudre Valley Hospital — Fort Collins, Colorado, United States
- Watson Clinic, LLC — Lakeland, Florida, United States
- Augusta Oncology Associates - Walton Way — Augusta, Georgia, United States
- Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
- Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler — Savannah, Georgia, United States
- Mobile Infirmary Medical Center — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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