MRS Measurement of Glutamate and GABA Metabolism in Brain

Recruiting now · Not applicable

Conditions studied: Normal Physiology

In brief

This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of \[13\]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA).

Key facts

Study ID

NCT00109174

Run by

National Institute of Mental Health (NIMH)

People needed

200

Starts

2006-09-06

Expected to finish

2030-03-11

Last updated by the study team

2026-07-28

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Any current Axis 1 diagnosis
• Clinically significant laboratory abnormalities
• Positive HIV test
• Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
• History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
• Prescription psychotropic medication; drug free less than 8 weeks (anticholinergics, benzodiazepine, fluoxetine, antipsychotics, and anticonvulsants)
• Serious medical illness as determined from H\&P or laboratory testing including Diabetes
• Inability to lie flat on camera bed for about two and a half hours
• Pregnant or breastfeeding
• Current substance use disorder based on DSM-5
• NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.

Where it is running

• National Institutes of Health Clinical Center — Bethesda, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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