Study of Escitalopram in Adult Patients With Major Depressive Disorder

Completed · Phase 3

Conditions studied: Major Depressive Disorder

In brief

Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults. This study is designed to evaluate the efficacy, safety, and pharmacoeconomics of escitalopram and an active comparator in patients with major depressive disorder.

Key facts

Study ID

NCT00108979

Run by

Forest Laboratories

People needed

240

Starts

2005-03-01

Expected to finish

2006-07-01

Last updated by the study team

2012-03-05

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must meet Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) diagnostic criteria for Major Depressive Disorder.
• The patient's current depressive episode must be at least 12 weeks in duration.

You may not qualify if…

• Women who are pregnant, women who will be breastfeeding during the study, and women of childbearing potential who are not practicing a reliable method of birth control.
• Patients who currently meet DSM-IV criteria for: a. bipolar disorder; b. schizophrenia or any psychotic disorder; c. obsessive-compulsive disorder; d. mental retardation or any pervasive developmental disorder or cognitive disorder.
• Patients who are considered a suicide risk.
• Patients with a history of seizure disorder, or any history of seizure, stroke, significant head injury, or any other condition that predisposes toward risk of seizure.

Where it is running

• Southwest Health, Ltd. — Phoenix, Arizona, United States
• Summit Research Network — Okemos, Michigan, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• Summit Research Network — Portland, Oregon, United States
• CNS Research Institute — Philadelphia, Pennsylvania, United States
• Clinical Neuroscience Solutions — Memphis, Tennessee, United States
• Radiant Research — Salt Lake City, Utah, United States
• Northwest Clinical Research Center — Bellevue, Washington, United States
• Summit Research Network — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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