Siblings With Ischemic Stroke Study

Completed

Conditions studied: Stroke

In brief

The purpose of this study is to find the genes that increase the risk of developing an ischemic stroke using DNA samples collected from concordant (stroke-affected) sibling pairs.

Key facts

Study ID

NCT00108940

Run by

Mayo Clinic

People needed

900

Starts

2000-12-01

Expected to finish

2011-06-01

Last updated by the study team

2011-09-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject diagnosed by a study neurologist as having had a symptomatic ischemic stroke in the past.
• Head Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) done within 7 days of symptom onset confirms absence of etiology other than ischemic stroke.
• Subject reports having at least one living sibling with a stroke.
• Subject is 18 years of age or older.

You may not qualify if…

• The index ischemic stroke occurred within 48 hours after a cardiovascular or cerebrovascular procedure.
• The index ischemic stroke occurred within 60 days after a non-traumatic subarachnoid hemorrhage.
• The subject has brain biopsy-proven central nervous system vasculitis.
• The subject is known to have any one of the following genetic disorders: CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), Fabry's disease, homocystinuria, MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, Stroke), or sickle cell anemia.
• The subject has a mechanical aortic valve or mechanical mitral valve.
• The subject had untreated or actively treated bacterial endocarditis at the time of the index ischemic stroke.

Where it is running

• University of South Alabama — Mobile, Alabama, United States
• Mayo Clinic Arizona — Scottsdale, Arizona, United States
• East Bay Region Assoc. — Berkeley, California, United States
• Scripps Clinic — La Jolla, California, United States
• University of California, Davis — Sacramento, California, United States
• Mercy General Hospital — Sacramento, California, United States
• Shands Jacksonville — Jacksonville, Florida, United States
• Mayo Clinic College of Medicine Jacksonville — Jacksonville, Florida, United States
• Florida Neurovascular Institute — Tampa, Florida, United States
• Cleveland Clinic - Florida — Weston, Florida, United States
• OSF St. Francis Medical Center — Peoria, Illinois, United States
• Indiana University/Clarian Health Partners — Indianapolis, Indiana, United States
• Mercy Medical Center — Sioux City, Iowa, United States
• University of Maryland — Baltimore, Maryland, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Rochester General Hospital — Rochester, New York, United States
• Helen Hayes Hospital — West Haverstraw, New York, United States
• Wake Forest University School of Medicine — Winston-Salem, North Carolina, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Metro Health — Cleveland, Ohio, United States
• Ohio State University — Columbus, Ohio, United States
• University of Penn. Med. Center — Philadelphia, Pennsylvania, United States
• Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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