Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance

Completed · Phase 4

Conditions studied: Glucose Metabolism Disorders, Diabetes

In brief

Subjects with impaired glucose tolerance will be randomized to receive pioglitazone or metformin for 10 weeks. Measurements of insulin sensitivity, body composition, glucose tolerance, and muscle lipid accumulation will be performed. Adipose tissue and muscle biopsies are performed. The goal of the study is to determine whether the lipotoxiciy of impaired glucose tolerance is ameliorated by pioglitazone.

Key facts

Study ID

NCT00108615

Run by

US Department of Veterans Affairs

People needed

48

Starts

2004-01-01

Expected to finish

2007-12-01

Last updated by the study team

2008-04-25

Who can join

Age: 35 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Impaired glucose tolerance
• Body mass index (BMI) of 28-38

You may not qualify if…

• Heart disease
• Renal disease
• Liver disease

Where it is running

• Central Arkansas Veterans HCS — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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