Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides

Completed · Phase 1

Conditions studied: Hypertriglyceridemia

In brief

The purpose of this study is to examine the role of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in triglyceride metabolism.

Key facts

Study ID

NCT00108511

Run by

US Department of Veterans Affairs

Starts

2004-10-01

Expected to finish

2007-09-01

Last updated by the study team

2009-01-21

Who can join

Age: 19 and older, up to 74. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age >18 and <75
• Fasting triglycerides >150 mg/dl

You may not qualify if…

• Fasting triglycerides >600 mg/dl
• LDL >130 mg/dl
• Concurrent lipid lowering therapy
• Known hypersensitivity to gemfibrozil
• Alcohol intake >30 gm/day (2 drinks/day)
• Fasting glucose >125 mg/dl or known type 2 diabetes
• AST or ALT > 2.0 x upper limit of normal
• Creatinine: men >1.4 mg/dl, women >1.3 mg/dl
• Cancer treatment in the past 5 years (unless cured)
• Infectious diseases including HIV or tuberculosis
• Significant cardiac disease in the past 6 months (myocardial infarction, coronary artery bypass graph, angioplasty, class 3 or 4 congestive heart failure, left bundle branch block, third degree AV block)
• Uncontrolled hypertension (systolic blood pressure [SBP] >180 or diastolic blood pressure [DBP] > 105 mm Hg)
• Anemia (hematocrit <40% men, <35% women)
• Any other significant systemic disease or medication that could interfere with tolerance of medication or outcome
• Any indication that a participant will be unable to adhere to the protocol
• Unable to give informed consent
• Pregnant or breastfeeding females or a female who plans to become pregnant while participating in the study

Where it is running

• Roudebush VA Medical Center — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.