Vasoconstrictors as Alternatives to Albumin After Large-Volume Paracentesis (LVP) in Cirrhosis

Completed · Phase 4 · Has a placebo group

Conditions studied: Ascites, Cirrhosis

In brief

This clinical trial compares a combination of two drugs that constrict blood vessels (Octreotide LAR and Midodrine) to albumin after large volume paracentesis. Subjects have cirrhosis and ascites.

Key facts

Study ID

NCT00108355

Run by

US Department of Veterans Affairs

People needed

29

Starts

2003-12-01

Expected to finish

2012-08-01

Last updated by the study team

2014-03-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cirrhosis of any etiology
• Age 18-80 years
• Moderate to severe ascites

You may not qualify if…

• No or small ascites
• Severe hepatic hydrothorax
• Recent GI (gastrointestinal) hemorrhage
• Active bacterial infection
• Cardiac failure
• Organic renal disease
• Hepatocellular carcinoma
• Severe comorbidity (advanced neoplasia)
• Serum creatinine > 3 mg/dl
• Pregnancy

Where it is running

• VA Connecticut Health Care System (West Haven) — West Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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