Brain Reaction to Treatment of Nicotine Dependence

Completed · Phase 1

Conditions studied: Nicotine Dependence

In brief

The purpose of the study was to determine how the treatments for cigarette craving work. Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.

Key facts

Study ID

NCT00108173

Run by

US Department of Veterans Affairs

People needed

104

Starts

2002-10-01

Expected to finish

2011-06-01

Last updated by the study team

2013-04-09

Who can join

Age: 21 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Heavy smoker, more than one pack per day
• Free of medical conditions or medications that affect brain activity
• Not pregnant

You may not qualify if…

• Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions

Where it is running

• VA Greater Los Angeles Healthcare System, West LA — West Los Angeles, California, United States

Full record on ClinicalTrials.gov

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