Topotecan, G-CSF, and Radiation Therapy in Treating Young Patients With Newly Diagnosed Brain Stem Glioma
Stopped early · Phase 1/Phase 2
Conditions studied: Brain Tumors, Central Nervous System Tumors
In brief
RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Colony-stimulating factors, such as G-CSF, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of chemotherapy. Radiation therapy uses high-energy x-rays to kill tumor cells. Topotecan may make tumor cells more sensitive to radiation therapy . Giving topotecan and G-CSF together with radiation therapy may be an effective treatment for brain stem glioma. PURPOSE: This phase I/II trial is studying the side effects and best dose of topotecan when given together with G-CSF and radiation therapy and to see how well they work in treating young patients with newly diagnosed brain stem glioma.
Key facts
- Study ID
- NCT00107471
- Run by
- Children's Oncology Group
- People needed
- 7
- Starts
- 2005-10-01
- Last updated by the study team
- 2013-12-10
Who can join
Age: 3 and older, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Phoenix Children's Hospital — Phoenix, Arizona, United States
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Southern California Permanente Medical Group — Downey, California, United States
- Children's Hospital Central California — Madera, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- Sutter Cancer Center — Sacramento, California, United States
- Stanford Comprehensive Cancer Center - Stanford — Stanford, California, United States
- Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center — Farmington, Connecticut, United States
- Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
- University of Florida Shands Cancer Center — Gainesville, Florida, United States
- Nemours Children's Clinic — Jacksonville, Florida, United States
- University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
- Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
- Nemours Children's Clinic - Orlando — Orlando, Florida, United States
- Sacred Heart Cancer Center at Sacred Heart Hospital — Pensacola, Florida, United States
- St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States
- Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
- St. Luke's Mountain States Tumor Institute - Boise — Boise, Idaho, United States
- University of Illinois Cancer Center — Chicago, Illinois, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- Advocate Christ Medical Center — Oak Lawn, Illinois, United States
- Saint Jude Midwest Affiliate — Peoria, Illinois, United States
- Indiana University Cancer Center — Indianapolis, Indiana, United States
- Lurleen Wallace Comprehensive Cancer at University of Alabama-Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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