Valproic Acid in Treating Young Patients With Recurrent or Refractory Solid Tumors or CNS Tumors
Completed · Phase 1
Conditions studied: Brain and Central Nervous System Tumors, Unspecified Childhood Solid Tumor, Protocol Specific
In brief
RATIONALE: Drugs used in chemotherapy, such as valproic acid, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Valproic acid may also stop the growth of solid tumors or CNS tumors by blocking blood flow to the tumor. PURPOSE: This phase I trial is studying the side effects and best dose of valproic acid in treating patients with recurrent or refractory solid tumors or CNS tumors.
Key facts
- Study ID
- NCT00107458
- Run by
- Children's Oncology Group
- People needed
- 26
- Starts
- 2005-05-01
- Expected to finish
- 2012-03-01
- Last updated by the study team
- 2014-08-07
Who can join
Age: 2 and older, up to 21. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Children's Hospital of Orange County — Orange, California, United States
- Stanford Comprehensive Cancer Center - Stanford — Stanford, California, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- Indiana University Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute — Boston, Massachusetts, United States
- University of Minnesota Children's Hospital - Fairview — Minneapolis, Minnesota, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center — New York, New York, United States
- SUNY Upstate Medical University Hospital — Syracuse, New York, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Oregon Health & Science University Cancer Institute — Portland, Oregon, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Baylor University Medical Center - Houston — Houston, Texas, United States
- Children's Hospital and Regional Medical Center - Seattle — Seattle, Washington, United States
- Hospital for Sick Children — Toronto, Ontario, Canada
- Hopital Sainte Justine — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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