S0433 Iodine I 131 Tositumomab, Rituximab, and Combination Chemotherapy in Treating Older Patients With Stage II, Stage III, or Stage IV Non-Hodgkin's Lymphoma
Completed · Phase 2
Conditions studied: Lymphoma
In brief
RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 tositumomab, can find cancer cells and carry cancer-killing substances to them without harming normal cells. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving a radiolabeled monoclonal antibody together with rituximab and combination chemotherapy may kill more cancer cells. PURPOSE: This phase II trial is studying how well giving iodine I 131 tositumomab together with rituximab and combination chemotherapy works in treating older patients with stage II, stage III, or stage IV B-cell non-Hodgkin's lymphoma.
Key facts
- Study ID
- NCT00107380
- Run by
- SWOG Cancer Research Network
- People needed
- 86
- Starts
- 2005-11-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2016-03-07
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Piedmont Hospital — Atlanta, Georgia, United States
- Northside Hospital Cancer Center — Atlanta, Georgia, United States
- Saint Joseph's Hospital of Atlanta — Atlanta, Georgia, United States
- CCOP - Atlanta Regional — Atlanta, Georgia, United States
- WellStar Cobb Hospital — Austell, Georgia, United States
- Charles B. Eberhart Cancer Center at DeKalb Medical Center — Decatur, Georgia, United States
- Gwinnett Medical Center — Lawrenceville, Georgia, United States
- Kennestone Cancer Center at Wellstar Kennestone Hospital — Marietta, Georgia, United States
- Southern Regional Medical Center — Riverdale, Georgia, United States
- Harbin Clinic Cancer Center - Medical Oncology — Rome, Georgia, United States
- Saint Anthony's Hospital at Saint Anthony's Health Center — Alton, Illinois, United States
- Cardinal Bernardin Cancer Center at Loyola University Medical Center — Maywood, Illinois, United States
- Good Samaritan Regional Health Center — Mount Vernon, Illinois, United States
- St. Francis Hospital and Health Centers - Beech Grove Campus — Beech Grove, Indiana, United States
- Reid Hospital & Health Care Services — Richmond, Indiana, United States
- Cotton-O'Neil Cancer Center — Topeka, Kansas, United States
- University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
- Saint Francis Medical Center — Cape Girardeau, Missouri, United States
- Midwest Hematology Oncology Group, Incorporated — St Louis, Missouri, United States
- CCOP - St. Louis-Cape Girardeau — St Louis, Missouri, United States
- David C. Pratt Cancer Center at St. John's Mercy — St Louis, Missouri, United States
- CCOP - Montana Cancer Consortium — Billings, Montana, United States
- Alaska Regional Hospital Cancer Center — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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