Study of Muraglitazar Versus Pioglitazone in Type 2 Diabetes

Completed · Phase 3

Conditions studied: Type 2 Diabetes Mellitus

In brief

The purpose of this study is to compare Muraglitazar and Pioglitazone in patients with Type 2 Diabetes. Both the safety and blood sugar lowering effects of these treatments will be studied.

Key facts

Study ID

NCT00106808

Run by

Bristol-Myers Squibb

People needed

1440

Starts

2005-08-01

Expected to finish

2006-08-01

Last updated by the study team

2010-09-14

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 2 Diabetes
• HbA1c > = 8.0% and < = 12.0%
• Serum triglyceride concentration < = 600 mg/dL
• Fasting c-peptide > = 1.0 ng/ml
• Body mass index < = 41 kg/m2
• Drug naive patients

You may not qualify if…

• History of MI (myocardial infarction), coronary angioplasty or bypass graft(s), valvular disease or repair, unstable angina pectoris, transient ischemic attack (TIA), cerebrovascular accidents, accelerated/malignant hypertension, or hypertension related CHF (congestive heart failure) within six months prior to screening and during the Lead-In Phase.
• Women of child Bearing Potential
• Uncontrolled hypertension, CHF defined as New York Heart Association (NYHA) Class II, III and IV, exacerbation of previously stable CHF (any NYHA class) or uncontrolled cardiac arrhythmia in the 30 days prior to screening and during the Lead-In Phase.
• History of renal disease, bladder cancer, pulmonary disease, gastrointestinal disease, active liver disease or endocrine disease.

Where it is running

• Local Institution — Columbiana, Alabama, United States
• Local Institution — Madison, Alabama, United States
• Local Institution — Glendale, Arizona, United States
• Local Institution — Mesa, Arizona, United States
• Local Institution — Peoria, Arizona, United States
• Local Institution — Phoenix, Arizona, United States
• Local Institution — Scottsdale, Arizona, United States
• Local Institution — Beverly Hills, California, United States
• Local Institution — Concord, California, United States
• Local Institution — Encinitas, California, United States
• Local Institution — Fresno, California, United States
• Local Institution — La Jolla, California, United States
• Local Institution — Los Angeles, California, United States
• Local Institution — Los Gatos, California, United States
• Local Institution — Orange, California, United States
• Local Institution — Pasadena, California, United States
• Local Institution — Roseville, California, United States
• Local Institution — Santa Monica, California, United States
• Local Institution — Colorado Springs, Colorado, United States
• Local Institution — Wilmington, Delaware, United States
• Local Institution — Boynton Beach, Florida, United States
• Local Institution — Charlotte Harbour, Florida, United States
• Local Institution — Chipley, Florida, United States
• Local Institution — Destin, Florida, United States
• Local Institution — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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