Genetic Characterization of Parkinson's Disease
Completed
Conditions studied: Parkinson Disease, PD, Movement Disorder, Healthy Volunteer, HV
In brief
This study will explore the risks and causes of Parkinson's disease, a chronic progressive nervous system disorder. Patients typically have tremors, muscle weakness and a shuffling gait. Patients with Parkinson's disease, their relatives and healthy volunteers may be eligible for this study. Candidates must be 18 years of age or older. Patients whose parkinsonism is due to a secondary cause, such as infection or injury, and healthy volunteers who have a first degree family member (parent, grandparent, child, sibling) with Parkinson's disease are excluded from enrollment. Participants are asked about possible symptoms they may have and about their general health. They provide a blood sample to obtain DNA for genetic analysis to look for genetic differences that might be related to risks for Parkinson's disease. White blood cells may be treated in the laboratory to grow a cell line, which provides a source of substances in the blood without having to draw samples repeatedly.
Key facts
- Study ID
- NCT00105131
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 2500
- Starts
- 2005-03-01
- Expected to finish
- 2005-11-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Individuals with Parkinson's disease OR
- Family members of an individual diagnosed with Parkinson's disease OR
- Healthy adult controls obtained through the NIH Clinical Research Volunteers Program (CVRP) or other healthy control volunteers who come forward.
You may not qualify if…
- Under the age of 18 years of age OR
- Individuals with Parkinsonism secondary to a specific cause such as toxin exposure, birth injury, head injury, or brain infection such as encephalitis.
- Healthy volunteers with a medical history or first degree family history of Parkinson's disease.
Where it is running
- National Institute of Neurological Disorders and Stroke (NINDS) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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