S0508: Thalidomide and Temozolomide in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery
Completed · Phase 2
Conditions studied: Melanoma (Skin)
In brief
RATIONALE: Thalidomide may stop the growth of melanoma by blocking blood flow to the tumor. It may also stimulate the immune system in different ways and stop tumor cells from growing. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving thalidomide together with temozolomide may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving thalidomide together with temozolomide works in treating patients with stage IV melanoma that cannot be removed by surgery.
Key facts
- Study ID
- NCT00104988
- Run by
- SWOG Cancer Research Network
- People needed
- 64
- Starts
- 2005-06-01
- Expected to finish
- 2009-08-01
- Last updated by the study team
- 2012-08-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Eden Medical Center — Castro Valley, California, United States
- North Bay Cancer Center — Fairfield, California, United States
- Saint Rose Hospital — Hayward, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Highland General Hospital at St. George's University School of Medicine — Oakland, California, United States
- Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Valley Care Medical Center — Pleasanton, California, United States
- Doctors Medical Center - San Pablo Campus — San Pablo, California, United States
- West Florida Cancer Institute at West Florida Hospital - Pensacola — Pensacola, Florida, United States
- Northeast Georgia Medical Center — Gainesville, Georgia, United States
- Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
- St. Luke's Mountain States Tumor Institute - Boise — Boise, Idaho, United States
- Decatur Memorial Hospital Cancer Care Institute — Decatur, Illinois, United States
- Veterans Affairs Medical Center - Hines — Hines, Illinois, United States
- Cardinal Bernardin Cancer Center at Loyola University Medical Center — Maywood, Illinois, United States
- Regional Cancer Center at Memorial Medical Center — Springfield, Illinois, United States
- Genesis Regional Cancer Center at Genesis Medical Center — Davenport, Iowa, United States
- Tammy Walker Cancer Center at Salina Regional Health Center — Salina, Kansas, United States
- Stormont-Vail Cancer Center — Topeka, Kansas, United States
- St. Francis Comprehensive Cancer Center — Topeka, Kansas, United States
- Wesley Medical Center — Wichita, Kansas, United States
- Christus Schumpert Cancer Treatment Center — Shreveport, Louisiana, United States
- Alaska Regional Hospital Cancer Center — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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