Study of the Effects of Current Drug Treatments on Levels of Certain Brain Chemicals in Alzheimer's Disease

Completed · Phase 4

Conditions studied: Alzheimer's Disease

In brief

Alzheimer's disease is a medical illness that damages the brain and causes problems with memory, mood and behavior. A substance called acetylcholine (ACh), which is naturally produced in the body, plays an important role in the normal functioning of the brain. In subjects with Alzheimer's disease, the level of ACh is greatly reduced. Currently, there are three commonly prescribed drugs used for treating the symptoms of Alzheimer's disease by helping to maintain the level of ACh in the brain. This study will evaluate how much each of these drugs changes the levels of certain brain chemicals that are known to, or may play an important role in, Alzheimer's disease and its symptoms.

Key facts

Study ID

NCT00104442

Run by

Novartis

People needed

80

Starts

2003-10-01

Expected to finish

2006-04-01

Last updated by the study team

2007-12-21

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of mild to moderate Alzheimer's disease
• Must be able to swallow capsule/tablet
• Must have a caregiver who is available to attend all study visits

You may not qualify if…

• Digestive problems related to peptic ulcer
• Experienced a heart attack or stroke in the last 6 months
• Serious/unstable asthma or severe pulmonary (lung) disease
• On current treatment with a blood thinner

Where it is running

• Novartis Pharmaceuticals — East Hanover, New Jersey, United States

Full record on ClinicalTrials.gov

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