Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth
Completed
Conditions studied: Gingival Overgrowth
In brief
This study will examine common features of gingival overgrowth (excessive growth of the gums around the teeth) that develops in patients with the hereditary form of the condition and in those who develop the condition as a side effect of medications. A better understanding of gingival overgrowth may help scientists develop medications with fewer oral side effects. Patients of any age with hereditary gingival fibromatosis and their blood relatives, and patients of any age with gingival overgrowth who are taking medications associated with development of the disorder, including phenytoin (diphenylhydantoin or Dilantin), cyclosporine, and calcium-channel blockers, may be eligible for this study. Participants undergo a medical and dental history, including a history of medication use; detailed examination of the teeth, periodontium, head, and neck; photographs of teeth with gingival overgrowth; dental x-rays; and blood tests. DNA is extracted from a blood sample to look for genes related to gingival overgrowth. Patients with gingival overgrowth are offered two options, as follows: * Tissue biopsy: A tissue sample is taken from each affected site, with a maximum of three biopsies. For the procedure, lidocaine is first injected into the gum to numb the tissue. Then, a cookie-cutter instrument is pushed into the numbed skin, and a small piece of tissue is removed. * Gingivectomy: Surgical removal of the overgrown gingival.
Key facts
- Study ID
- NCT00104026
- Run by
- National Institute of Dental and Craniofacial Research (NIDCR)
- People needed
- 45
- Starts
- 2005-02-15
- Expected to finish
- 2011-04-19
- Last updated by the study team
- 2017-07-02
Who can join
Age: 2 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Patients with significant cognitive impairment.
- Pregnant patients or lactating patients.
- Patients unwilling to give informed consent.
- Patients with less than six teeth.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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