Safety and Activity Study of an Oral Medication to Treat Moderate to Severe Crohn's Disease

Completed · Phase 2

Conditions studied: Crohn Disease

In brief

The purpose of this research study is to investigate the effects of an investigational medication, called CCX282-B, on safety and on the some of the symptoms of Crohn's Disease in patients who are experiencing an active flare-up of moderate to severe Crohn's Disease.

Key facts

Study ID

NCT00102921

Run by

Amgen

People needed

70

Starts

2004-08-01

Expected to finish

2005-12-01

Last updated by the study team

2025-03-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of moderate to severe Crohn's Disease in small intestine; disease must be active at the time of study entry
• Use of adequate and approved methods of birth control throughout the study period
• Willing and able to sign an informed consent

You may not qualify if…

• Pregnant or breastfeeding
• Infection with hepatitis B, hepatitis C, or human immunodeficiency virus (HIV; the virus that causes AIDS)
• Abuse of alcohol or of illegal drugs

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Rocky Mountain Clincal Research — Golden, Colorado, United States
• Arapahoe Gastroenterology — Littleton, Colorado, United States
• Atlanta Gastroenterology Associates — Atlanta, Georgia, United States
• University of Chicago — Chicago, Illinois, United States
• Mayo Clinic Rochester — Rochester, Minnesota, United States
• Comprehensive Clinical Research — Berlin, New Jersey, United States
• Long Island Clinical Research Associates, LLP — Great Neck, New York, United States
• Wake Forest Research — Raleigh, North Carolina, United States
• University Hospitals of Cleveland, Div of Gastroenterology — Cleveland, Ohio, United States
• Digestive Disease Clinic — Jackson, Tennessee, United States
• Nashville Medical Research Institute — Nashville, Tennessee, United States
• Center for Colon Rectal Disease — Salt Lake City, Utah, United States
• University of Virginia Health System, Digestive Health Center of Excellence — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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