YM443 in Subjects With Functional Dyspepsia

Completed · Phase 2

Conditions studied: Indigestion, Nausea

In brief

The primary objective of this study will be to characterize the dose response profile of YM443 in subjects with functional dyspepsia (FD) to enable the selection of doses for the Phase 3 clinical trial.

Key facts

Study ID

NCT00102310

Run by

Astellas Pharma Inc

People needed

416

Starts

2004-03-10

Expected to finish

2006-03-11

Last updated by the study team

2018-01-10

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to read and write in English.
• Written informed consent has been obtained.
• 18-75 years of age on the day the Informed Consent Form is signed.
• Men or women.
• Females, not pregnant, lactating or likely to become pregnant.
• Abdominal ultrasound and/or upper endoscopy findings that are judged as not clinically significant by the Investigator during Screening or within 4 weeks prior to Screening.
• Symptoms of FD at Visits 1 and 4 as defined by Rome II criteria.
• Subjects with a positive H. pylori breath test at Screening may be included in the study.
• Subjects with pH-metry results at Screening indicative of reflux may be included in the study.
• ECG, vital signs, and laboratory results that are judged as not clinically significant by the Investigator during Screening.

You may not qualify if…

• Significant renal, hepatic, bilirubin, cardiovascular, pulmonary, endocrine, metabolic, hematological, neurologic, or gastrointestinal (other than the one being studied) condition.
• Subjects with diabetes mellitus are to be excluded.
• Congenital or acquired long QT syndrome, or uncontrolled arrhythmias.
• Prior surgery on the luminal GI tract.
• History of any major psychiatric disorder, current depression or anxiety, alcohol abuse, or substance abuse in the last 2 years.
• Any evidence or treatment for malignancy (with the exception of basal cell carcinoma) within the last 5 years.
• Confirmed structural gastrointestinal disease.
• Predominant symptoms of irritable bowel syndrome (IBS) (Rome II criteria) or gastroesophageal reflux disease (GERD) assessed at Visit 1 or 4.
• Female subjects who are pregnant, lactating, or are likely to become pregnant during the study.
• Males and females of child-bearing potential must be abstinent or agree to use contraceptive regimens throughout the study.
• Any history or condition which, in the opinion of the Investigator, makes the subject unsuitable for any of the procedures used during this study or would not allow for safe completion of the study.
• Known hypersensitivity to gastroprokinetics or proton pump inhibitors.
• Use of anti-ulcer medications, antacid/acid suppression medications, gastroprokinetics, aspirin (>325 mg daily), other NSAIDs, antibiotics, and other medications that effect the GI system within 2 weeks prior to Screening. Must be able to stay off these medications during the study, except for proton pump inhibitors (PPIs) administered during the PPI Run-in Period.
• Required use of concomitant medications known to adversely interact with other gastroprokinetic agents or proton pump inhibitors.
• H. pylori eradication therapy (PPIs, antibiotics, bismuth preparations) in the 2 weeks prior to the upper endoscopy.
• Treatment for H. pylori required during the study.
• Subject has received an investigational drug within 30 days or 10 half-lives, which ever is longer, or participated in more than 3 clinical studies within 12 months, prior to Visit 1.
• Previous treatment with YM443.
• Employees of the Yamanouchi Group or CROs involved in the study.
• More than one subject per household to participate in the study.

Where it is running

• James Thrasher, MD — Little Rock, Arkansas, United States
• Dr. Dennis Riff — Anaheim, California, United States
• Dr. Peter Winkle — Cypress, California, United States
• Dr. Ramin Farsad — Encinitas, California, United States
• Dr. Prahalad Jajodia — Fresno, California, United States
• Dr. Gurmej Dhillon — Fresno, California, United States
• Dr. Steven Duckor — Orange, California, United States
• Dr. Theodor Feinstat — Roseville, California, United States
• Scott Levenson, MD — San Carlos, California, United States
• Dr. Michael Bennett — San Diego, California, United States
• Dr. William Snape — San Francisco, California, United States
• Dr. Abbass Shafii — Colorado Springs, Colorado, United States
• Dr. Julio Salcedo — Washington D.C., District of Columbia, United States
• Dr. Daniel Maico — Gainesville, Florida, United States
• Dr. Simon Behar — Hialeah, Florida, United States
• Wayne Schonfeld, MD — Hollywood, Florida, United States
• Dr. Stephen Palte — Atlanta, Georgia, United States
• Dr. Nathan Segall — Atlanta, Georgia, United States
• Azazuddin Ahmed, MD — Oak Brook, Illinois, United States
• Brian Covey, MD — Dubuque, Iowa, United States
• Dr. Richard McCallum — Kansas City, Kansas, United States
• Robert Braun, MD — Topeka, Kansas, United States
• Carroll Steinfeld, MD — Madisonville, Kentucky, United States
• David Dulitz, MD — Metairie, Louisiana, United States
• Dr. Suresh Karne — Huntsville, Alabama, United States

Full record on ClinicalTrials.gov

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