Study of Talaporfin Sodium Photodynamic Therapy to Treat Advanced Age Related Macular Disease

Stopped early · Phase 1

Conditions studied: Macular Degeneration, Choroidal Neovascularization

In brief

The purpose of this study is to determine the safety and tolerability of Talaporfin Sodium (LS11) Photodynamic Therapy in patients with late stage Age-Related Macular Disease (AMD).

Key facts

Study ID

NCT00102115

Run by

Light Sciences LLC

People needed

27

Starts

2004-12-01

Expected to finish

2006-01-01

Last updated by the study team

2010-03-12

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 50 or older
• Subject is able to sign informed consent
• Ability to complete 6 month trial
• Present with advanced AMD and persistently leaking CNV
• Adequate hematologic, renal and liver function
• Negative pregnancy test
• Subject is able to safely undertake all protocol directed instructions
• Visual acuity of 20/200 (logMAR 1.0)(6/60) or worse

You may not qualify if…

• Concomitant eye disease in eye to be treated
• Prior ocular radionuclide treatments
• Known allergic or hypersensitivity reactions to light and/or fluorescein and iodine or shellfish
• History of investigational drug or therapy including biologics within 30 days prior to the study drug dosing
• Women who are pregnant or lactating, or women of childbearing years not taking adequate contraception precautions
• History of porphyria, systemic lupus erythematosus, or xeroderma pigmentosum
• History of clinically significant cardiovascular abnormalities, including myocardial infarction in the past 6 months, uncontrolled arrhythmias, uncontrolled congestive heart failure
• Concomitant use of other drugs known to produce skin photosensitivity, e.g. tetracycline, sulfonamides, phenothiazines, sulfonylureas, thiazide diuretics and griseofulvin, St. John's Wort
• Subjects with high or pathological myopia with an axial length > 26mm or a refractive error of >/= -8.00D
• Subjects with glaucoma and vision loss in either eye
• Subject with a history of other choroidal leakage, e.g. histoplasmosis
• Subjects with significant media opacity
• Subjects diagnosed with diabetic retinopathy
• Subjects who have had eye surgery within the past 3 months
• Subjects who have received PDT treatment for AMD in the treatment eye
• Any disease or condition that the sponsor or the investigator believes will impact the subject's ability to adhere to the study schedule
• Subjects participating in any concurrent trial

Where it is running

• Texas Retina — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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