Docetaxel, Gemcitabine, and Filgrastim (G-CSF) or Pegfilgrastim in Treating Patients With Advanced, Persistent, or Recurrent Uterine Leiomyosarcoma

Completed · Phase 2

Conditions studied: Sarcoma

In brief

RATIONALE: Drugs used in chemotherapy, such as docetaxel and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Colony-stimulating factors, such as G-CSF and pegfilgrastim, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of chemotherapy. Giving docetaxel and gemcitabine together with G-CSF or pegfilgrastim may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving docetaxel and gemcitabine together with G-CSF or pegfilgrastim works in treating patients with advanced, persistent, or recurrent uterine leiomyosarcoma.

Key facts

Study ID

NCT00101127

Run by

Gynecologic Oncology Group

Starts

2003-12-01

Last updated by the study team

2014-02-14

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

Where it is running

• Jonsson Comprehensive Cancer Center at UCLA — Los Angeles, California, United States
• Helen and Harry Gray Cancer Center at Hartford Hospital — Hartford, Connecticut, United States
• New Britain General Hospital — New Britain, Connecticut, United States
• CCOP - Christiana Care Health Services — Newark, Delaware, United States
• MBCCOP-Medical College of Georgia Cancer Center — Augusta, Georgia, United States
• Medical Center of Central Georgia — Macon, Georgia, United States
• Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
• Rush-Copley Cancer Care Center — Aurora, Illinois, United States
• Rush University Medical Center — Chicago, Illinois, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• Hinsdale Hematology Oncology Associates — Hinsdale, Illinois, United States
• Joliet Oncology-Hematology Associates, Limited - West — Joliet, Illinois, United States
• Carle Cancer Center at Carle Foundation Hospital — Urbana, Illinois, United States
• CCOP - Carle Cancer Center — Urbana, Illinois, United States
• Saint Anthony Memorial Health Centers — Michigan City, Indiana, United States
• Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
• Woman's Hospital — Baton Rouge, Louisiana, United States
• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Ellis Fischel Cancer Center at University of Missouri - Columbia — Columbia, Missouri, United States
• CCOP - Kansas City — Kansas City, Missouri, United States
• CCOP - Cancer Research for the Ozarks — Springfield, Missouri, United States
• St. John's Regional Health Center — Springfield, Missouri, United States
• Hulston Cancer Center at Cox Medical Center South — Springfield, Missouri, United States
• Kaiser Permanente Medical Center - Los Angeles — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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