Risperidone Treatment for Military Service Related Chronic Post Traumatic Stress Disorder
Completed · Phase 2 · Has a placebo group
Conditions studied: Stress Disorders, Post-Traumatic
In brief
The purpose of this research of 400 participants is to determine whether a drug called risperidone can decrease symptoms of Post-Traumatic Stress Disorder (PTSD). It is a placebo-controlled study, meaning that half of the participants will be assigned to receive a pill that contains no drug. The treatment phase of the study will last for 6 months, during which time participants will continue to receive all their usual treatments in addition to the study treatment and will be asked to complete procedures and assessments (questionnaires, interviews, laboratory tests, physical exams, etc.) related to their PTSD symptoms at various points within the 6-month treatment phase. At the end of the 6-month study, participants will discontinue the study treatment.
Key facts
- Study ID
- NCT00099983
- Run by
- US Department of Veterans Affairs
- People needed
- 296
- Starts
- 2006-10-01
- Expected to finish
- 2011-01-01
- Last updated by the study team
- 2014-08-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years or older
- Military service related chronic PTSD
- CAPS score >50
- Participant in VA outpatient PTSD clinic
- History of non-response to two or more antidepressants
You may not qualify if…
- Comorbid Axis I diagnosis requiring antipsychotic medication
- Substance dependence diagnosis (excluding nicotine)
- Hepatic or renal problems
- Incompatible medical diagnosis or medication (i.e., coumadin, insulin)
- Unstable living arrangements
- Assault or suicide gesture within 1 year
Where it is running
- VA Medical Center, Tuscaloosa — Tuscaloosa, Alabama, United States
- VA San Diego Healthcare System, San Diego — San Diego, California, United States
- VA Medical Center, San Francisco — San Francisco, California, United States
- VA Greater Los Angeles Healthcare System, West LA — West Los Angeles, California, United States
- VA Connecticut Health Care System (West Haven) — West Haven, Connecticut, United States
- VA Medical Center, Miami — Miami, Florida, United States
- Atlanta VA Medical and Rehab Center, Decatur — Decatur, Georgia, United States
- Jesse Brown VAMC (WestSide Division) — Chicago, Illinois, United States
- VA Maryland Health Care System, Baltimore — Baltimore, Maryland, United States
- VA Medical Center, Jamaica Plain Campus — Boston, Massachusetts, United States
- VA Medical Center, Minneapolis — Minneapolis, Minnesota, United States
- New Mexico VA Health Care System, Albuquerque — Albuquerque, New Mexico, United States
- VA Medical Center, Durham — Durham, North Carolina, United States
- VA Medical Center, Providence — Providence, Rhode Island, United States
- Ralph H Johnson VA Medical Center, Charleston — Charleston, South Carolina, United States
- Michael E. DeBakey VA Medical Center (152) — Houston, Texas, United States
- VA South Texas Health Care System, San Antonio — San Antonio, Texas, United States
- Central Texas Veterans Health Care System — Temple, Texas, United States
- VA Salt Lake City Health Care System, Salt Lake City — Salt Lake City, Utah, United States
- Wlliam S. Middleton Memorial Veterans Hospital, Madison — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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