Curcumin in Patients With Mild to Moderate Alzheimer's Disease

Completed · Phase 2

Conditions studied: Alzheimer's Disease

In brief

The purpose of this study is to examine the safety and tolerability of curcumin, and to determine its effect on patients with mild to moderate Alzheimer's Disease (AD).

Key facts

Study ID: NCT00099710
Run by: John Douglas French Foundation
People needed: 33
Starts: 2003-07-01
Expected to finish: 2007-12-01
Last updated by the study team: 2009-12-03

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Male or female at least 50 years old
Diagnosis of probable AD
No history of significant psychiatric or non-AD neurological disease
Proficient in English to be able to perform cognitive testing
Caregiver available to monitor and administer medication and to accompany patient to every clinical visit
On stable doses of cholinesterase inhibitors and memantine (Alzheimer's medications) for 3 months prior to enrollment
On stable doses of all other allowed medications for at least one month prior to starting the study medication

You may not qualify if…

Current or recent major psychiatric illness (i.e. bipolar disorder, schizophrenia)
Significant, uncontrolled systemic illness (i.e. chronic renal failure, chronic liver disease, poorly controlled diabetes, or poorly controlled congestive heart failure)
Recent history of gastrointestinal bleeding or ulceration
Alcoholism or substance abuse within the past year
Familial, autosomal dominant Alzheimer's disease due to a mutation in a known gene (Presenilin-1, Presenilin-2, or Amyloid Precursor Protein)
NSAIDs (e.g. ibuprofen, naproxen, etc.) taken on a regular basis (more than 3 times per week)
Aspirin at doses more than 325 mg per day
Coumadin, heparin, other anticoagulants
Antioxidants or other supplements including gingko biloba, coenzyme Q10, alpha-lipoic acid
Vitamin E at doses more than 2,000 IU per day
Vitamin C at doses more than 500 mg per day

Where it is running

UCLA Medical Center — Westwood, Los Angeles, California, United States

Full record on ClinicalTrials.gov

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