CALERIE (Washington University): Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy

Completed · Phase 1

Conditions studied: Aging

In brief

This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. The three sites that are participating in the CALERIE trial represent a diversity of subject populations and interventional strategies.

Key facts

Study ID

NCT00099138

Run by

National Institute on Aging (NIA)

People needed

48

Starts

2002-03-01

Expected to finish

2006-02-01

Last updated by the study team

2009-12-11

Who can join

Age: 50 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 50 to 60
• Women must be post-menopausal
• Normal weight to moderately overweight, (Body Mass Index [BMI] between 23 - 30)
• In good health, free of major chronic diseases or conditions
• Well motivated
• Reliable

You may not qualify if…

• Major chronic disease or condition that would interfere with exercise or caloric restriction (such as diabetes, coronary artery disease, significant obstructive airway disease, stroke, resting blood pressure over 170 mmHg systolic and/or 100 mmHg diastolic, history or evidence of malignancy, orthopedic or musculoskeletal problems)
• Hormone replacement therapy (DHEA, estrogen, thyroid, testosterone)
• Regular exercise twice or more per week
• Smoking
• Alcoholism
• Frequent travel

Where it is running

• Washington University in St. Louis, School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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